GFR CKD EPI Calculation

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

Unit Converter ▲

Unit Converter ▼

From:	To:

1. What Is The GFR CKD EPI Calculation?

The GFR CKD EPI Calculation uses the CKD-EPI 2021 equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated equation provides improved accuracy in assessing kidney function compared to previous versions.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The equation incorporates updated coefficients and exponents based on recent research, providing more precise GFR estimation across different population groups.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding appropriate clinical management decisions.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What's New In The CKD-EPI 2021 Equation?
A: The 2021 version features updated coefficients (142 instead of 141, -1.200 instead of -1.209) and refined gender-specific parameters for improved accuracy.

Q2: How Does This Compare To The Original CKD-EPI?
A: The 2021 equation provides better performance in diverse populations and has been validated against more contemporary reference standards.

Q3: What Are The Clinical Applications?
A: Used for CKD screening, staging, monitoring disease progression, and adjusting medication dosages based on kidney function.

Q4: Are There Population Limitations?
A: While improved, the equation may still have limitations in specific populations like the elderly, pregnant women, and those with extreme body compositions.

Q5: When Should This Equation Be Used?
A: Recommended for routine clinical practice when serum creatinine measurements are available, particularly for initial assessment and monitoring of kidney function.