GFR CKD EPI Calc Low

Low GFR CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the Low GFR CKD-EPI Equation?

The Low GFR CKD-EPI equation is a specialized version of the CKD-EPI formula optimized for estimating glomerular filtration rate (GFR) in patients with reduced kidney function. It provides enhanced accuracy for lower GFR ranges compared to the standard equation.

2. How Does the Calculator Work?

The calculator uses the Low GFR CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for patients with reduced kidney function, using different coefficients than the standard CKD-EPI equation to improve accuracy in the lower GFR range.

3. Importance of Low GFR Calculation

Details: Accurate GFR estimation in the low range is critical for proper staging of chronic kidney disease, guiding treatment decisions, and determining eligibility for specialized interventions and transplant evaluation.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. This calculator is optimized for patients with suspected or confirmed reduced kidney function (eGFR < 60 mL/min/1.73m²).

5. Frequently Asked Questions (FAQ)

Q1: When should I use the Low GFR CKD-EPI equation?
A: Use this equation when you suspect or have confirmed reduced kidney function (eGFR < 60 mL/min/1.73m²) for improved accuracy in this range.

Q2: How does this differ from standard CKD-EPI?
A: This version uses different coefficients (142, -1.200, 0.9938) and gender multipliers optimized for lower GFR ranges.

Q3: What are the CKD stages based on eGFR?
A: Stage 1: ≥90, Stage 2: 60-89, Stage 3: 30-59, Stage 4: 15-29, Stage 5: <15 mL/min/1.73m².

Q4: Are there limitations to this equation?
A: Like all estimation equations, it may be less accurate in extremes of age, body composition, or with rapidly changing kidney function.

Q5: Should this replace measured GFR?
A: For critical decisions like drug dosing or transplant evaluation, measured GFR may still be necessary in certain clinical scenarios.