CKD-EPI Equation:
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The GFR CKD EPI (Chronic Kidney Disease Epidemiology Collaboration) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This blood test provides an accurate assessment of kidney function and is widely used in clinical practice.
The calculator uses the CKD-EPI equation:
Where:
Explanation: The equation accounts for non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups.
Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing.
Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120).
Q1: Why Use CKD-EPI Equation?
A: CKD-EPI provides more accurate GFR estimation across different age groups and kidney function levels compared to older equations.
Q2: What Are Normal eGFR Values?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.
Q3: When Should Creatinine Be Measured?
A: Morning fasting sample is ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.
Q4: Are There Limitations To This Equation?
A: Less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function.
Q5: Should This Be Used For Drug Dosing?
A: For precise drug dosing, measured GFR (e.g., via iohexol clearance) may be needed in certain populations.