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Pediatric Cystatin C Equation:
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The Pediatric Cystatin C equation estimates glomerular filtration rate (GFR) specifically for children using serum cystatin C levels. Cystatin C is a more reliable marker in pediatric populations as it is less influenced by muscle mass and diet compared to creatinine.
The calculator uses the Pediatric Cystatin C equation:
Where:
Explanation: This equation provides a simple and accurate method for estimating GFR in pediatric patients using cystatin C, which is produced at a constant rate and freely filtered by the glomeruli.
Details: Accurate GFR estimation in children is essential for detecting kidney dysfunction early, monitoring chronic kidney disease progression, and adjusting medication dosages appropriate for pediatric renal function.
Tips: Enter serum cystatin C in mg/L. The value must be greater than 0. This calculator is specifically validated for pediatric populations.
Q1: Why use cystatin C instead of creatinine in children?
A: Cystatin C is less affected by muscle mass, diet, and gender differences, making it more reliable in pediatric populations where these factors vary significantly.
Q2: What age range is this equation validated for?
A: This equation is specifically designed and validated for pediatric patients, typically from 1 year to 18 years of age.
Q3: What are normal eGFR values in children?
A: Normal eGFR values in children are generally higher than adults and vary by age. Values typically range from 90-140 mL/min/1.73m² in healthy children.
Q4: Are there limitations to this equation?
A: This equation may be less accurate in children with extreme body compositions, inflammatory conditions, or thyroid disorders that can affect cystatin C production.
Q5: When should cystatin C be measured in children?
A: Cystatin C is particularly useful when creatinine-based estimates are unreliable, such as in malnourished children, those with muscle wasting, or when precise GFR estimation is critical.