Calculator eGFR CKD EPI

CKD-EPI 2021 Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI 2021 Equation?

The CKD-EPI 2021 equation is an updated version that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This refined equation provides improved accuracy in assessing kidney function across diverse populations.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: The 2021 equation features updated coefficients that provide more accurate GFR estimation, particularly in populations with preserved kidney function.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for early detection of chronic kidney disease, monitoring disease progression, and guiding clinical decisions regarding medication dosing and treatment strategies.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What's new in the CKD-EPI 2021 equation?
A: The 2021 version features updated coefficients (142, -1.200, 0.9938) and gender-specific parameters that improve accuracy across different population groups.

Q2: How does this compare to the original CKD-EPI equation?
A: The 2021 equation provides more refined estimates with updated constants and exponents, offering improved precision in GFR calculation.

Q3: What are the clinical applications of this calculator?
A: Useful for screening, diagnosis, and monitoring of chronic kidney disease, as well as for medication dose adjustments in patients with renal impairment.

Q4: Are there population limitations?
A: While improved, the equation may still have limitations in extreme age groups, pregnant women, and populations with unusual muscle mass or diet.

Q5: When should this equation be used?
A: Recommended for routine clinical practice when serum creatinine measurements are available, particularly for initial assessment and follow-up of kidney function.