1. What is eGFR in CKD?

eGFR (estimated glomerular filtration rate) in chronic kidney disease using CKD-EPI equation provides an accurate assessment of kidney function by estimating how well the kidneys are filtering waste from the blood.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( \kappa \) — 0.7 (female) or 0.9 (male)
• \( \alpha \) — -0.241 (female) or -0.302 (male)
• \( age \) — Age in years
• 1.012 — Female multiplier

Explanation: This equation provides a more precise estimation of kidney function across different demographic groups and creatinine levels.

3. Importance of eGFR Calculation

Details: Accurate eGFR calculation is essential for diagnosing chronic kidney disease stages, monitoring disease progression, and making informed treatment decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the clinical significance of eGFR?
A: eGFR helps classify chronic kidney disease stages and guides treatment decisions including medication dosing and referral to nephrology.

Q2: How often should eGFR be monitored?
A: Frequency depends on CKD stage and clinical context, typically every 3-12 months for stable patients.

Q3: What factors can affect eGFR accuracy?
A: Muscle mass, diet, medications, and hydration status can influence serum creatinine levels and thus eGFR calculations.

Q4: When is this equation most accurate?
A: The CKD-EPI equation performs well across a wide range of GFR values and is particularly accurate in early stages of kidney disease.

Q5: Are there population-specific considerations?
A: While generally accurate, some ethnic groups may require specific validation or adjustment factors.