1. What is eGFR from Creatinine?

This equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. It provides an accurate assessment of kidney function based on creatinine levels and demographic factors.

2. How Does the Calculator Work?

The calculator uses the eGFR from creatinine equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( \kappa \) — 0.7 (female) or 0.9 (male)
• \( \alpha \) — -0.241 (female) or -0.302 (male)
• \( age \) — Age in years
• 1.012 — Female multiplier

Explanation: The equation accounts for the non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing decisions.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between this equation and CKD-EPI?
A: This equation uses different coefficients (142, -1.200, 0.9938) and does not include race adjustment, providing an alternative method for eGFR estimation.

Q2: What are normal eGFR values?
A: Normal eGFR is generally ≥90 mL/min/1.73m², though values naturally decline with age. Below 60 for 3+ months indicates chronic kidney disease.

Q3: When is the best time to measure creatinine?
A: Morning fasting samples are ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age and weight, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Can this be used for drug dosing?
A: For precise drug dosing, measured GFR may be needed in certain high-risk populations.