Calculated eGFR Renal Function

Renal Function Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The Calculated eGFR Renal Function?

The Calculated eGFR Renal Function equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This specialized equation provides accurate assessment of kidney function for clinical evaluation and monitoring.

2. How Does The Calculator Work?

The calculator uses the renal function equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation models the non-linear relationship between serum creatinine levels and glomerular filtration rate, with optimized coefficients for different demographic characteristics.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing renal impairment, staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal clearance.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What Is The Clinical Significance Of This Equation?
A: This equation provides a reliable estimate of glomerular filtration rate, which is crucial for assessing kidney function and detecting renal impairment early.

Q2: What Are Normal eGFR Values?
A: Normal eGFR is generally ≥90 mL/min/1.73m². Values between 60-89 may indicate mild reduction, while values below 60 for three months or more suggest chronic kidney disease.

Q3: When Should Serum Creatinine Be Measured?
A: Morning fasting samples are preferred, though random samples are acceptable. Avoid testing immediately after high-protein meals or intense physical activity.

Q4: Are There Limitations To This Equation?
A: Accuracy may be reduced in extreme age groups, patients with unusual muscle mass, amputees, pregnant women, and those with rapidly changing renal function.

Q5: Can This Equation Be Used For Drug Dosing?
A: While useful for initial assessment, precise drug dosing may require measured GFR in specific clinical situations or for medications with narrow therapeutic windows.