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eGFR ≈ CrCl: Approximate eGFR from measured or estimated creatinine clearance, as they are often used interchangeably though not identical.
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This calculator approximates glomerular filtration rate (eGFR) from measured or estimated creatinine clearance (CrCl). While eGFR and CrCl are often used interchangeably in clinical practice, they represent different but related measures of kidney function.
The calculator uses direct approximation:
Where:
Explanation: While eGFR and CrCl are not identical measures, they are often used interchangeably in clinical practice for drug dosing and kidney function assessment.
Details: Estimating GFR from creatinine clearance provides a standardized measure of kidney function that accounts for body surface area, making it useful for comparing kidney function across different individuals.
Tips: Enter creatinine clearance value in mL/min. The calculator will provide an approximate eGFR value. Note that this is an approximation and may not be suitable for all clinical scenarios.
Q1: Are eGFR and CrCl the same?
A: No, they are related but different measures. eGFR is standardized to body surface area (1.73m²), while CrCl is the actual measured clearance rate.
Q2: When is this approximation appropriate?
A: This approximation is commonly used in clinical practice for drug dosing and initial kidney function assessment, but for precise measurements, specific equations should be used.
Q3: What are the limitations of this approach?
A: The approximation may be less accurate in extremes of body size, elderly patients, and those with unstable kidney function.
Q4: How is creatinine clearance measured?
A: CrCl can be measured via 24-hour urine collection or estimated using equations like Cockcroft-Gault.
Q5: Which is more accurate - eGFR or CrCl?
A: For most clinical purposes, eGFR is preferred as it's standardized. However, for specific drug dosing, CrCl may be recommended by some guidelines.