Calcolo GFR Con CKD EPI

Italian CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the Italian CKD-EPI Creatinine Equation?

The Italian CKD-EPI equation is a modified version of the standard CKD-EPI equation specifically validated for Italian populations. It estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex, providing accurate assessment of kidney function tailored to Italian demographic characteristics.

2. How Does the Calculator Work?

The calculator uses the Italian CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation incorporates population-specific coefficients optimized for Italian individuals, providing more accurate GFR estimates in this demographic.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing in Italian populations.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: Why use the Italian CKD-EPI equation?
A: The Italian version is specifically calibrated for Italian populations and may provide more accurate results than the standard CKD-EPI equation in this demographic.

Q2: What are normal eGFR values for Italian populations?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.

Q3: How does this differ from standard CKD-EPI?
A: It uses different coefficients (142 vs 141, different alpha values, and 0.9938 vs 0.993) optimized for Italian population data.

Q4: Should race be considered in this calculation?
A: The Italian version does not include race adjustment as it was developed specifically for Italian populations.

Q5: Is this equation validated for all Italian regions?
A: The equation was developed and validated across multiple Italian centers and is considered applicable for the general Italian population.