Calcolo GFR Secondo CKD EPI

Italian CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The Italian CKD-EPI Creatinine Equation?

The Italian CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation is a modified version that estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex specifically validated for the Italian population. It provides accurate assessment of kidney function tailored to regional demographics.

2. How Does The Calculator Work?

The calculator uses the Italian CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for the Italian population and accounts for demographic variations in creatinine metabolism and kidney function.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation using population-specific equations is crucial for diagnosing chronic kidney disease, determining disease stage, and guiding medication dosing in the Italian healthcare context.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). This calculator is specifically designed for Italian population data.

5. Frequently Asked Questions (FAQ)

Q1: Why Use The Italian CKD-EPI Equation?
A: This version is specifically validated for the Italian population, providing more accurate results for this demographic group compared to the standard CKD-EPI equation.

Q2: What Are Normal eGFR Values For Italians?
A: Normal is generally ≥90 mL/min/1.73m², though values may vary slightly based on regional and demographic factors specific to Italy.

Q3: When Should Creatinine Be Measured?
A: Morning fasting sample is ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are There Limitations To This Equation?
A: This equation is specifically validated for Italian adults. It may be less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Should This Be Used For Drug Dosing In Italian Patients?
A: For precise drug dosing in Italian patients, this equation provides population-specific estimates, though measured GFR may be needed in certain clinical situations.