Calcolo GFR CKD EPI

Italian GFR CKD-EPI Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What Is The Italian GFR CKD-EPI Equation?

The Italian GFR CKD-EPI equation is a modified version of the CKD-EPI equation specifically validated for Italian populations. It estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex, providing accurate assessment of kidney function.

2. How Does The Calculator Work?

The calculator uses the Italian CKD-EPI equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation is specifically calibrated for Italian populations and provides improved accuracy for estimating kidney function in this demographic group.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate treatment strategies in Italian populations.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: Why Use The Italian CKD-EPI Equation?
A: This equation is specifically validated for Italian populations and may provide more accurate results than the standard CKD-EPI equation for individuals of Italian descent.

Q2: What Are Normal eGFR Values For Italian Populations?
A: Normal eGFR values are generally ≥90 mL/min/1.73m², though values naturally decline with age. Values below 60 mL/min/1.73m² for 3+ months indicate chronic kidney disease.

Q3: When Should Creatinine Be Measured?
A: Morning fasting samples are ideal, but random samples are acceptable. Avoid testing after protein-rich meals or strenuous physical activity.

Q4: Are There Limitations To This Equation?
A: The equation may be less accurate in elderly patients, individuals with extreme body weights, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Can This Equation Be Used For Drug Dosing?
A: While useful for estimating kidney function, for precise drug dosing in critical situations, measured GFR methods may be necessary.