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CKiD Cystatin C Equation:
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The CKiD (Chronic Kidney Disease in Children) cystatin C equation estimates glomerular filtration rate (GFR) specifically for pediatric patients using serum cystatin C levels. It provides an accurate assessment of kidney function in children without the need for creatinine measurements.
The calculator uses the CKiD cystatin C equation:
Where:
Explanation: The equation uses the inverse relationship between cystatin C levels and GFR, with cystatin C being less influenced by muscle mass compared to creatinine.
Details: Cystatin C-based GFR estimation is particularly valuable in pediatric populations where muscle mass varies significantly and creatinine levels may not accurately reflect true kidney function.
Tips: Enter serum cystatin C in mg/L. The value must be greater than 0. This calculator is specifically designed for pediatric patients.
Q1: Why use cystatin C instead of creatinine in children?
A: Cystatin C is less affected by muscle mass, diet, and physical activity, making it more reliable in pediatric populations where these factors vary widely.
Q2: What are normal cystatin C levels in children?
A: Normal cystatin C levels typically range from 0.5-1.2 mg/L in children, but reference ranges may vary by age and laboratory.
Q3: When should cystatin C be measured in pediatric patients?
A: When accurate GFR estimation is needed, especially in children with abnormal muscle mass, malnutrition, or when creatinine-based estimates are questionable.
Q4: Are there limitations to this equation?
A: This equation is specifically validated for pediatric populations. It may not be accurate in adults or in patients with thyroid dysfunction or corticosteroid use.
Q5: How does this compare to creatinine-based equations in children?
A: Cystatin C-based equations often provide more accurate GFR estimates in children, particularly those with reduced muscle mass or nutritional issues.