CKD EPI NKF Calculator

CKD-EPI NKF Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the CKD-EPI NKF Equation?

The CKD-EPI NKF (Chronic Kidney Disease Epidemiology Collaboration National Kidney Foundation) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This version provides a refined calculation method for assessing kidney function.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI NKF equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation uses updated coefficients for more precise GFR estimation across different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing chronic kidney disease, monitoring disease progression, and determining appropriate treatment strategies.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What distinguishes CKD-EPI NKF from standard CKD-EPI?
A: The NKF version uses refined coefficients (142, -1.200, 0.9938, 1.012) for potentially improved accuracy in specific populations.

Q2: What are the clinical applications of this calculator?
A: Used for kidney function assessment, CKD staging, and guiding clinical decisions in nephrology practice.

Q3: When is the best time to measure serum creatinine?
A: Morning fasting samples are preferred, but random samples can be used with appropriate clinical interpretation.

Q4: Are there population limitations for this equation?
A: May be less accurate in extreme age groups, pregnant women, and individuals with unusual muscle mass.

Q5: Can this calculator be used for medication dosing?
A: While useful for estimation, critical medication dosing may require more precise GFR measurement methods.