1. What is the CKD-EPI 2021 Creatinine Equation?

The CKD-EPI 2021 (Chronic Kidney Disease Epidemiology Collaboration) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This updated version provides improved accuracy and eliminates race as a variable in the calculation.

2. How Does the Calculator Work?

The calculator uses the CKD-EPI 2021 equation:

Where:

• \( Scr \) — Serum creatinine (mg/dL)
• \( \kappa \) — 0.7 (female) or 0.9 (male)
• \( \alpha \) — -0.241 (female) or -0.302 (male)
• \( age \) — Age in years
• 1.012 — Female multiplier

Explanation: The equation accounts for non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups. The 2021 version removes race adjustment for more equitable assessment.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is crucial for diagnosing chronic kidney disease, determining disease stage, guiding medication dosing, and monitoring kidney function over time.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What's new in the CKD-EPI 2021 equation?
A: The 2021 version removes race as a variable and uses updated coefficients for improved accuracy across diverse populations.

Q2: What are normal eGFR values?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.

Q3: When should creatinine be measured?
A: Morning fasting sample is ideal, but random samples are acceptable. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are there limitations to this equation?
A: Less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function.

Q5: Why was race removed from the equation?
A: Race was removed to provide more equitable kidney function assessment and eliminate potential health disparities.