Australian eGFR Calculator

CKD-EPI Equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times (1.159 \text{ if black}) \]

Serum Creatinine (Scr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What Is The Australian eGFR Calculator?

The Australian eGFR Calculator uses the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation to estimate glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. This calculator is specifically adapted for Australian clinical practice and provides a more accurate assessment of kidney function than older equations.

2. How Does The Calculator Work?

The calculator uses the CKD-EPI equation:

\[ eGFR = 141 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.209} \times 0.993^{age} \times (1.018 \text{ if female}) \times (1.159 \text{ if black}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.329 (female) or -0.411 (male)
\( age \) — Age in years
1.018 — Female multiplier
1.159 — Black race multiplier

Explanation: This equation accounts for the non-linear relationship between creatinine and GFR, with different coefficients for different demographic groups as validated in Australian populations.

3. Importance Of eGFR Calculation

Details: Accurate GFR estimation is crucial in Australian healthcare for diagnosing chronic kidney disease, determining disease stage according to Australian guidelines, and guiding appropriate medication dosing for Australian patients.

4. Using The Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120). This calculator follows Australian clinical practice standards.

5. Frequently Asked Questions (FAQ)

Q1: Why Use CKD-EPI In Australian Practice?
A: CKD-EPI is recommended in Australian guidelines as it's more accurate at higher GFR levels (>60 mL/min/1.73m²) and provides better classification of kidney function in diverse Australian populations.

Q2: What Are Normal eGFR Values For Australians?
A: Normal is generally ≥90 mL/min/1.73m², though values naturally decline with age. Below 60 for 3+ months indicates chronic kidney disease according to Australian standards.

Q3: When Should Creatinine Be Measured In Australian Practice?
A: Morning fasting sample is preferred in Australian laboratories, but random samples are acceptable for screening. Avoid testing after meat-heavy meals or vigorous exercise.

Q4: Are There Limitations For Australian Populations?
A: The equation performs well in most Australian populations but may be less accurate in Indigenous Australians, extremes of age/weight, and those with rapidly changing kidney function.

Q5: Should This Be Used For Drug Dosing In Australia?
A: For precise drug dosing in Australian clinical practice, measured GFR may be needed in certain high-risk populations, though eGFR is widely used for initial dosing guidance.