American Kidney GFR Calculator

American Kidney GFR Equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Estimated GFR (eGFR):

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1. What is the American Kidney GFR Equation?

The American Kidney GFR equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. This equation provides a specialized assessment of kidney function developed by American nephrology researchers.

2. How Does the Calculator Work?

The calculator uses the American Kidney GFR equation:

\[ eGFR = 142 \times \min(Scr/\kappa, 1)^\alpha \times \max(Scr/\kappa, 1)^{-1.200} \times 0.9938^{age} \times (1.012 \text{ if female}) \]

Where:

\( Scr \) — Serum creatinine (mg/dL)
\( \kappa \) — 0.7 (female) or 0.9 (male)
\( \alpha \) — -0.241 (female) or -0.302 (male)
\( age \) — Age in years
1.012 — Female multiplier

Explanation: This equation incorporates specific coefficients optimized for the American population, providing accurate GFR estimation across different demographic groups.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for detecting early kidney dysfunction, monitoring disease progression, and making informed clinical decisions about treatment and medication adjustments.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, and select gender. Ensure all values are valid (creatinine > 0, age between 1-120 years) for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: How does this equation differ from CKD-EPI?
A: The American Kidney GFR equation uses different coefficients (142, -1.200, 0.9938) specifically calibrated for American populations and may provide more accurate results in this demographic.

Q2: What are the clinical applications of this equation?
A: This equation is particularly useful for screening and monitoring kidney function in American patient populations and for research studies focusing on this demographic.

Q3: When is the best time to measure creatinine?
A: Morning fasting samples are preferred, but random samples can be used. Avoid testing immediately after high-protein meals or intense physical activity.

Q4: Are there population limitations?
A: This equation is specifically validated for American populations. Caution should be exercised when applying it to other ethnic groups or special populations.

Q5: Can this be used for medication dosing?
A: While useful for estimating kidney function, for critical medication dosing decisions, consult specific dosing guidelines and consider measured GFR when necessary.